Mucosal vaccination with a recombinant OprF-I vaccine of Pseudomonas aeruginosa in healthy volunteers: comparison of a systemic vs. a mucosal booster schedule

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• 作者：Gö ; cke ; Kerstin ; Baumann ; Ulrich ; Hagemann ; Hartmut ; Gabelsberger ; Josef ; Hahn ; Heinz ; et. al.
• 关键词：Mucosal vaccination ; Systemic booster ; Serum antibody ; Pseudomonas aeruginosa
• 刊名：FEMS Immunology and Medical Microbiology
• 出版年：2003
• 出版时间：July 15, 2003
• 年：2003
• 卷：37
• 期：2-3
• 页码：167-171
• 全文大小：170 K

文摘

We compared the immunogenicity of two vaccination schedules with either a systemic or a mucosal booster, both following a mucosal primary vaccination with a recombinant outer membrane fusion protein of Pseudomonas aeruginosa (OprF-I) in 12 healthy volunteers. The systemic booster induced higher levels of OprF-I-specific serum antibodies of IgG isotype, with a mean±S.E.M. of 32.6±7.8×10⁷ enzyme-linked immunosorbent assay (ELISA) units (EU) as compared to the nasal booster with 14.6±2.1×10⁷ EU (P