Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease
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- 作者：Sara Sepe1 ; Chiara Milanese1 ; 2 ; Sylvia Gabriels1 ; Kasper W.J. Derks1 ; Cesar Payan-Gomez1 ; 3 ; Wilfred F.J. van IJcken4 ; Yvonne M.A. Rijksen1 ; Alex L. Nigg5 ; Sandra Moreno6 ; Silvia Cerri7 ; Fabio Blandini7 ; Jan H.J. Hoeijmakers1 ; Pier G. Mastroberardino1 ; p.g.mastroberardino@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：31 May 2016
- 年：2016
- 卷：15
- 期：9
- 页码：1866-1875
- 全文大小：4711 K
文摘
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Ercc1-mediated DNA repair is necessary for preservation of dopaminergic neurons
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Mouse mutants with mild Ercc1 defects display signs of dopaminergic pathology
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Mild Ercc1 dysfunction is sensitized to the prototypical PD neurotoxin MPTP
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PD patients’ peripheral cells exhibit inefficient nucleotide excision repair