Combined radiochemotherapy of locally advanced unresectable pancreatic adenocarcinoma with mitomycin C plus 24-hour continuous infusional gemcitabine
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- 作者：Kornek ; Gabriela V. ; Pö ; tter ; Richard ; Selzer ; Edgar ; Schratter ; Annemarie ; Ulrich-Pur ; Herbert ; et. al.
- 关键词：Combined-treatment modality ; Gemcitabine ; Mitomycin C ; Pancreatic carcinoma ; Radiation therapy
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2001
- 出版时间：March 1, 2001
- 年：2001
- 卷：49
- 期：3
- 页码：665-671
- 全文大小：72.5 K
文摘
Background: In locally advanced pancreatic cancer, the combination of chemotherapy with radiotherapy is gaining increasing importance; although, in view of the reported long-term results of several contemporary trials, further improvements are certainly warranted. The aim of the present study was to evaluate the effectiveness and safety of a combined-treatment modality consisting of systemic chemotherapy with 24-h continuous infusional gemcitabine and mitomycin C, plus external beam radiotherapy in patients with localized unresectable adenocarcinoma of the pancreas.