Power consumption measurement and temperature recording during granulation

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• 作者：Betz ; Gabriele ; Bü ; rgin ; Pascale Junker ; Leuenberger ; Hans
• 关键词：Granulation ; Power consumption ; Temperature control ; In process control ; Formulation design
• 刊名：International Journal of Pharmaceutics
• 出版年：2004
• 出版时间：March 19, 2004
• 年：2004
• 卷：272
• 期：1-2
• 页码：137-149
• 全文大小：125 K

文摘

This study was performed to elucidate the influences of process and formulation design using power consumption and temperature measurements during granulation. Power consumption was recorded “in process” using a previously introduced computer program for optimal end-point detection at an early stage. The temperature increase (ΔT) during granulation was recorded using a temperature sensor. The temperature increase in the wet powder bed expresses the friction forces at interparticle contacts occurring during granulation. The maxima of temperature profile occurred at 130 % saturation, whereas the maxima of power consumption were determined at 100 % saturation. The ratio of temperature and power consumption (TPR factor) is introduced as a signature of formulation design. TPR factor was found to be dependent on particle size, particle surface, water absorption capacity and solubility of the excipient and model drug, respectively. However, TPR factor was found to be independent of process design, such as the filling level of the mixer.