Downregulation of glutamatergic and GABAergic proteins in valproric acid associated social impairment during adolescence in mice
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- 作者：Davor Kin-Fan Chau1 ; Angus Yiu-Ting Choi1 ; Wen Yang ; Wing Nang Leung ; Chun Wai Chan ; francischan.2010@gmail.com" class="auth_mail" title="E-mail the corresponding author ; fcwchan@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ASD ; autism spectrum disorder ; BDNF ; brain derived neurotrophic factor ; DSM-V ; diagnostic and statistical manual for mental disorders ; E ; embryonic day ; GABAAR ; γ-aminobutyric acid subtype A receptors ; GAD65 ; glutamic acid decarboxylases 65 ; kDa ; GAD67 ; glutamic acid decarboxylases 67 ; kDa ; GABRA1 ; GABAAR subunit α1 ; GABRA5 ; GABAAR subunit α5 ; GABRB2 ; GABAAR subunit β2 ; NMDAR ; N-methyl-d-aspartate receptor ; NR2A ; NMDAR subunit 2A ; NR2B ; NMDAR subunit 2B ; NR2C ; NMDAR subunit 2C ; PND ; post
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：255-260
- 全文大小：1193 K
文摘
NMDAR subunits 2A, 2B, 2C were downregulated in the cortices of VPA-induced autistic adolescent mice.
GABAAR subunits GABRA1, GABRA5 and GABRB2 were downregulated in the cortices of VPA-induced autistic adolescent mice.
Glutamic acid decarboxylase GAD65 and GAD67 were downregulated in the cortices of VPA-induced autistic adolescent mice.
BDNF was downregulated in the cortices of VPA-induced autistic adolescent mice.