Modification of acquired immunity in BALB/c mice by aztreonam

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• 作者：Ortega ; Elena ; de Pablo ; Manuel A. ; Gaforio ; José ; Juan ; Gallego ; Aurelia M^a ; et. al.
• 关键词：Beta-lactams ; Aztreonam ; Acquired immunity ; Antibody response ; Cytokines ; Lympho-monocytic populations
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2000
• 出版时间：July, 2000
• 年：2000
• 卷：15
• 期：3
• 页码：193-199
• 全文大小：85.7 K

文摘

Recent studies have suggested that antibiotics may act as biological response modifiers. In this study we investigated the effect of aztreonam, a monobactam antibiotic, on different parameters of acquired immunity in BALB/c mice. Different dosages of aztreonam injected into mice induced an increase in the lymphoproliferative response to specific mitogens and in the production of interleukin-2 by splenic cells, as well as a decreased response of this immune population to sheep erythrocytes, lower total blood cell counts and a lower percentage of monocytes than in untreated mice. These results show a modulatory action of aztreonam on different immune parameters, which is independent of its antimicrobial activity and that could be of interest in human therapy.