Ultrasound assisted multicomponent reactions: A green method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular reusable catalyst in water
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- 作者：Asha V. Chate ; Umesh B. Rathod ; Jagdish S. Kshirsagar ; Pradip A. Gaikwad ; Kishor D. Mane ; Pravin S. Mahajan ; Mukesh D. Nikam ; Charansingh H. Gill<sup> ; sup><sup>chgill16@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Tandem reaction ; N-Substituted 1 ; 8-dioxo-decahydroacridines ; β-Cyclodextrin ; Supramolecular catalysis ; Water
- 刊名：Chinese Journal of Catalysis
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：37
- 期：1
- 页码：146-152
- 全文大小：857 K
文摘
We demonstrate a superficial method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular, biodegradable, and reusable catalyst in aqueous medium. The reaction product is in excellent yield with moderate to excellent selectivity. The mechanistic transformation presumably proceeds via a one-pot, multicomponent cyclization of dimedone in the presence of aromatic aldehydes and aromatic amines/INH, undergoing a tandem Michael addition reaction. The proposed approach in this study provides a highly efficient and environmentally benign route to N-substituted 1,8-dioxo-decahydroacridines.