The role of neuropeptide CART in the lateral hypothalamic-ventral tegmental area (LH-VTA) circuit in motivation
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- 作者：Amita R. Somalwara ; 1 ; Gajanan P. Shelkara ; 1 ; Nishikant K. Subhedarb ; nksubhedar@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Dadasaheb M. Kokarea ; kokaredada@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CART ; Reward ; LH-MFB ; pVTA ; AcbSh
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：340-349
- 全文大小：4088 K
文摘
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Intracranial self-stimulation (ICSS) was facilitated by CART.
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ICSS resulted in robust activation of CART cells in the LH.
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ICSS induced synaptic plasticity in CART system in reward circuit.
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Rats can be conditioned to self-administer CART in pVTA.
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CART neurons of LH-MFB may process motivation via the mesolimbic dopamine pathway.