Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats
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- 作者：Rajnish M. Dhediya<sup> ; sup><sup>rajnish_dr@yahoo.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Shirish S. Joshi ; Snehalata V. Gajbhiye ; Sharmila V. Jalgaonkar ; Mansij Biswas
- 关键词：Epilepsy ; Sodium valproate ; Elevated plus maze ; Malondialdehyde ; Glutathione
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：153-157
- 全文大小：441 K
文摘
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Pentylenetetrazole (PTZ)- induced kindled rats are associated with impairment of memory and oxidative stress.
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S-adenosyl methionine (SAM) had antiepileptic property in PTZ- induced kindling model in rats.
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SAM prevents memory impairment in PTZ- induced kindling model.
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Memory enhancing potential of SAM could be due to its antioxidant property.
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Antioxidant and memory enhancing property of SAM could have beneficial role in the treatment of epilepsy.