- 作者：David Vega-Morales ; drdavidvega@yahoo.com.mx ; Jorge Antonio Esquivel-Valerio ; Roberto Negrete-Ló ; pez ; Dionicio Á ; ngel Galarza-Delgado ; Mario Alberto Garza-Elizondo
- 关键词：Bursitis ; Treatment ; Metilprednisolona ; Anserine syndrome
- 刊名：Reumatolog¡§aa Cl¡§anica (English Edition)
- 出版年：2012
- 出版时间：March-April, 2012
- 年：2012
- 卷：8
- 期：2
- 页码：63-67
- 全文大小：181 K
Objective
The anserine syndrome is a common cause of knee pain. Infiltration with glucocorticoids has been evaluated in studies with low level of evidence and there are no published clinical trials to determine its usefulness. The objective of this study was to determine the efficacy and safety of the infiltration of methylprednisolone in the treatment of anserin syndrome.Methods
We conducted a clinical trial in 58 adult patients with anserin syndrome, which presented intra-articular pathology ruled that reflected pain in the medial aspect of the knee. The WOMAC scale was assessed at baseline and patients were randomized to receive an infiltration of lidocaine plus 40 mg methylprednisolone acetate (group 1) versus xylocaine plus distilled water (group 2). Both groups received 100 mg of diclofenac sodium for 10 days. The WOMAC scale was applied at 4 weeks and adverse events were recorded.
Results
Equivalence was demonstrated in both groups for demographic variables and initial clinical evaluation. There was no statistical difference in the 3 domains of assessment of the baseline WOMAC score. The median baseline WOMAC in group 1 was 32 and in group 2 was 25.5 points. At 4 weeks it was 8 and 6.5 points, which corresponded to an improvement of 61.6 % and 62.8 % , respectively.
Conclusion
The infiltration with methylprednisolone in anserin syndrome is not superior to placebo in patients taking diclofenac measured by the WOMAC scale at 4 weeks. The incidence of adverse events did not show any differences either.