• 作者：Leire Martí ; n Otañ ; o^a ; ^{lamartintzi@hotmail.com} ; Laura Barbadillo Izquierdo^a ; Ander Galdeano Mondragó ; n^a ; Marta Alonso Pinedo^a ; Imanol Querejeta Ayerdi^a ; ^b
• 关键词：Agentes antipsicó ; ticos ; Sí ; ndrome X metabó ; lico ; Trastornos psicó ; ticos ; Primer episodio psicó ; tico
• 刊名：Revista de Psiquiatr¡§aa y Salud Mental
• 出版年：2013
• 出版时间：January-March, 2013
• 年：2013
• 卷：6
• 期：1
• 页码：26-32
• 全文大小：327 K

Introduction

The morbidity and mortality due to cardiovascular causes in patients with schizophrenia is higher than in the general population, a fact that has been observed more since second generation anti-psychotics came into general use.

Objectives

To determine the incidence of metabolic syndrome in patients with a previously untreated first psychotic episode, as well as the prospective changes in the parameters that define the criteria of metabolic syndrome.

Method

An observational study with a prospective cohort design including patients who were admitted to the Acute Unit of Donostia Hospital.

Results

A total of 21 patients were included in the study, of which 19 completed it. Just over one-quarter (26.3 % ) of the patients developed a metabolic syndrome at six months. Statistically significant differences were observed in the following parameters: 1) abdominal perimeter measurement with an increase of 14.6 cm at six months (P=.001); 2) triglyceride levels with a mean increase over the initial measurement of 48.99 mg/dl (P=.039); and 3) fasting blood glucose levels with a mean increase of 10.72 mg/dl (P=.001).

Conclusions

Significant changes were observed in metabolic parameters in a short period with the subsequent risk of associated cardiovascular events in a group of young patients. Actions are required directed at ensuring appropriate monitoring of these patients in order to measures to minimise the risks.