Glyceraldehyde 3-phosphate dehydrogenase and galectin from Dirofilaria immitis participate in heartworm disease endarteritis via plasminogen/plasmin system
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- 作者：Javier Gonzá ; lez-Miguela ; jglez@usal.es" class="auth_mail" title="E-mail the corresponding author ; Carmen Larrazabala ; Diana Loa-Mesó ; na ; Mar Siles-Lucasb ; Fernando Simó ; na ; Rodrigo Morchó ; na
- 关键词：Dirofilaria immitis ; Fibrinolysis ; Plasmin ; Glyceraldehyde 3-phosphate dehydrogenase ; Galectin ; Proliferative endarteritis
- 刊名：Veterinary Parasitology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：223
- 期：Complete
- 页码：96-101
- 全文大小：2192 K
文摘
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rDiGAPDH and rDiGAL have been recently identified as PLG-binding proteins.
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rDiGAPDH and rDiGAL + PLG produce proliferation of CnAOEC and CnAOSMC.
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rDiGAPDH and rDiGAL + PLG produce migration of CnAOEC and CnAOSMC.
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rDiGAPDH and rDiGAL + PLG produce ECM degradation of CnAOEC and CnAOSMC.
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All these mechanisms are related to the appearance of proliferative endarteritis.