- 作者：Leticia Seoane ; Sonia P茅rtega ; Rita Galeiras ; Iv谩n Astola ; Teresa Bouza
- 关键词：Burns ; Procalcitonin ; Sepsis ; Diagnosis ; Intensive care
- 刊名：Burns
- 出版年：March, 2014
- 年：2014
- 卷：40
- 期：2
- 页码：223-229
- 全文大小：409 K
Objective
To determine the usefulness of procalcitonin (PCT) in decision-making when faced with suspected infection in patients with extensive burns.Study
Retrospective, observational follow-up study.
Institution
Burn Unit of the Complexo Hospitalario Universitario A Coru帽a (CHUAC), Spain.
Patients and method
We included all patients admitted to the Unit from June 2011 to March 2012 with 鈮?0% total body surface area burned or 鈮?0% full-thickness body surface area burned with suspected infection (17 patients with 34 events of suspected infection).
Results
The infections were confirmed in 16/34 episodes (47.1%), and documented in 44.1% (n = 15). There were no statistically significant differences in the PCT figures at the time the infection was suspected between the cases with confirmed and unconfirmed infection (p = 0.682). The PCT values showed no discriminative value for differentiating patients with SIRS from those with sepsis, severe sepsis and septic shock (area under ROC curve (AUC) = 0.546; 95% CI: 0.326-0.766). No significant correlation was found between SOFA and PCT, although there were differences in the PCT values in the patients who had tissue hypoperfusion.
Conclusion
Results show that PCT is not a precise indicator of sepsis at the time of diagnosis. A correlation between PCT levels and hypoperfusion was observed.