Clinical testing of propofol geriatic dose for sedation designed via in silico trial
详细信息 查看全文
- 作者：Ana Gabriela Gallardo-Hernandeza ; Ana Luisa Hernandez-Pereza ; anagabygh@gmail.com" class="auth_mail" title="E-mail the corresponding author ; German Ordoñ ; ez-Espinosab ; Antonio Sanchez-Lopezb ; Cristina Revilla-Monsalvea ; Sergio Islas-Andradea
- 关键词：Propofol ; In silico trial ; Sedation ; BIS monitor
- 刊名：Computer Methods and Programs in Biomedicine
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：132
- 期：Complete
- 页码：21-27
- 全文大小：938 K
文摘
- •
Anesthesia for patients older than 65 years represents more risk due to age-related physiological changes and the multiple co-morbidities they often present.
- •
A computer simulation study showed that lower than conventional doses of propofol were adequate to sedate the elderly.
- •
A clinical trial validated the new dose scheme.
- •
Using a lower dose in the elderly minimizes the secondary effects of propofol.