Intrahepatic cholestasis of pregnancy: A risk factor for cancer, autoimmune and cardiovascular diseases?

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• 作者：Serge Erlinger ; ^{serge.erlinger@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Clinics and Research in Hepatology and Gastroenterology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：40
• 期：2
• 页码：139-140
• 全文大小：331 K

文摘

The authors show, in an elegant population-based study, a significant association between intrahepatic cholestasis of pregnancy and liver and biliary cancer. This association is most probably related to the high frequency of hepatitis C and gallstone disease in women with intrahepatic cholestasis of pregnancy, both being risk factors for liver and biliary cancer. In addition, the study clearly shows an increased risk of diabetes mellitus and autoimmune diseases, such as thyroid diseases, psoriasis, autoimmune arthropathies and Crohn's disease, and a small increase in cardiovascular diseases. In practice, a follow-up of liver function tests 6–12 weeks after delivery is strongly recommended to detect a possible associated liver disease.