PXR- and CAR-mediated herbal effect on human diseases
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- 作者：Chenshu Xub ; Min Huanga ; Huichang Bia ; bihchang@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABC ; ATP-binding cassette ; AD ; Alzheimer's disease ; AhR ; aryl hydrocarbon receptor ; CAR ; constitutive androstane receptor ; CARKO ; CAR-knockout ; CGD ; cholesterol gallstone disease ; CPT1 ; carnitine palmitoyltransferase 1 ; CYP ; cytochrome P450 ; DBD ; DNA-binding domain ; DIM ; diindolylmethane ; ECI ; enoyl-CoA isomerase ; EEPA ; ethanol extract of Phyllanthus amarus ; GBE ; Ginkgo biloba extract ; G6Pase ; glucose-6-phosphatase ; GST ; glutathione S-transferase ; IBD ; inflammatory bowel disease ; LBD ; ligand-bin
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1859
- 期：9
- 页码：1121-1129
- 全文大小：545 K
文摘
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Nuclear receptor PXR and CAR regulate a number of genes encoding drug metabolizing enzymes and transporters.
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Increasing herbal extract and their active components have been identified as PXR and/or CAR ligands.
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PXR and CAR are involved in the herbal effect against multiple human diseases.
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Pharmacological targeting of PXR/CAR with herbal compounds may be an effective therapeutic strategy against human diseases.