Synthesis and NMR analysis of model compounds related to fucosylated chondroitin sulfates: GalNAc and Fuc(1 → 6)GalNAc derivatives

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• 作者：Dmitry Z. Vinnitskiy ; Nadezhda E. Ustyuzhanina ; ^{ustnad@gmail.com} ; Andrey S. Dmitrenok ; Alexander S. Shashkov ; Nikolay E. Nifantiev ; ^{nen@ioc.ac.ru}
• 关键词：Fucosylated chondroitin sulfate ; Oligosaccharide ; Synthesis ; Glycosylation ; NMR ; Spectral glycosylation effect ; Spectral sulfation effect
• 刊名：Carbohydrate Research
• 出版年：2017
• 出版时间：13 January 2017
• 年：2017
• 卷：438
• 期：Complete
• 页码：9-17
• 全文大小：931 K
• 卷排序：438

文摘

Selectively sulfated derivatives of GalNAc and α-Fuc-(1 → 6)-GalNAc were synthesized. Fucosyl bromide was applied for stereoselective 6-O-α-L-fucosylation. NMR effects of sulfation and fucosylation were calculated. Obtained NMR-data are vital for the development of computer assisted analysis of natural FCS.