文摘
This study aims to investigate the association of neonatal indiredt hyperbilirubinemia in breast-fed infants with UGT1A1 polymorphism. There was a statistically high significant decrease in weight at sample collection and high significant increase in indirect bilirubin level in patients group compared to control group. There was statistically significant difference as regard to genotype frequency [G/G, G/A, A/A], and allele frequency (A,G) between patients and control group. There was statistically significant increase in indirect bilirubin level in G/A – A/A genotypes. By comparing subgroup (A) and subgroup (B). There was statistically significant increase in total bilirubin level in subgroup (B). There was statistically high significant difference regarding genotype frequency (G/G, G/A, A/A) and allele frequency (G, A) between subgroup A and B. Multiple stepwise regression analysis was done using hyperbilirubinemia as a dependent factor and body weight loss, genotype (G/A) and allele (A) as independent factors. Body weight loss, genotype (G/A) and allele (A) was found to be significant independent predictors for hyperbilirubinemia.