Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an acute rat model of temporal lobe epilepsy
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- 作者：Fabio Carletti ; fabio.carletti@unipa.it" class="auth_mail" title="E-mail the corresponding author ; Giuditta Gambino giuditta.gambino@unipa.it" class="auth_mail" title="E-mail the corresponding author ; Valerio Rizzo valerio.rizzo@unipa.it" class="auth_mail" title="E-mail the corresponding author ; Giuseppe Ferraro giuseppe.ferraro@unipa.it" class="auth_mail" title="E-mail the corresponding author ; Pierangelo Sardo pierangelo.sardo@unipa.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hippocampus ; Temporal lobe epilepsy ; Cannabinoids ; TRPV1 ; Capsaicin ; Electrophysiology
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：56-65
- 全文大小：2057 K
文摘
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r0005">The TRPV1 agonist, capsaicin, increases paroxysmal activity in MDA model.
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r0010">The antagonist capsazepine protects from epileptiform discharges.
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r0015">Pretreatment with capsaicin impairs antiepileptic action of WIN.
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r0020">Co-administration with capsazepine enhances WIN protection from epileptic events.
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r0025">CB and TRPV1 cross-talk in the modulation of hyperexcitability in experimental TLE.