miRNA-149* promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia
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- 作者：Sheng-jin Fan ; Hui-bo Li ; Gang Cui ; Xiao-lin Kong ; Li-li Sun ; Yan-qiu Zhao ; Ying-hua Li ; liyinghua1965@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Jin Zhou
- 关键词：miRNA-149* ; JunB ; T-ALL ; Proliferation ; Apoptosis
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：62-70
- 全文大小：2346 K
文摘
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miRNA-149* was upregulated in T-ALL cells and T-ALL patients’ bone marrow samples.
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JunB was a target of miR-149*, and miRNA-149* mimics downregulated JunB levels.
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miRNA-149* mimics promoted proliferation and reduced cell apoptosis in T-ALL cells.
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miRNA-149* mimics downregulated p21 and upregulated cyclinD1, 4EBP1, and p70s6k.
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miRNA-149* inhibitors exhibited opposite effects.