Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity

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• 作者：Danielle M. Friend¹ ; ⁹ ; Kavya Devarakonda¹ ; ⁹ ; Timothy J. O&rsquo ; Neal¹ ; ⁹ ; Miguel Skirzewski⁵ ; Ioannis Papazoglou¹ ; Alanna R. Kaplan² ; Jeih-San Liow⁴ ; Juen Guo¹ ; Sushil G. Rane¹ ; Marcelo Rubinstein⁶ ; ⁷ ; ⁸ ; Veronica A. Alvarez² ; Kevin D. Hall¹ ; Alexxai V. Kravitz¹ ; ³ ; ¹⁰ ; ^{lex.kravitz@nih.gov}
• 关键词：obesity ; dopamine ; physical activity ; exercise ; D2 ; striatum ; obese ; weight loss
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：312-321
• 全文大小：2888 K
• 卷排序：25

文摘

Obesity is associated with physical inactivity Obese mice have less striatal D2R binding, which may explain their inactivity Restoring Gi signaling in iMSNs rescues physical activity levels of obese mice Physical inactivity is more a consequence than a cause of weight gain