Changes in SK channel expression in the basal ganglia after partial nigrostriatal dopamine lesions in rats: Functional consequences

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• 作者：Christiane Mourre^a ; ¹ ; Christine Manrique^b ; ¹ ; Jeremy Camon^a ; Sabrine Aidi-Knani^a ; Thierry Deltheil^a ; Nathalie Turle-Lorenzo^b ; Gaelle Guiraudie-Capraz^c ; Marianne Amalric^a ; ^{marianne.amalric@univ-amu.fr}
• 关键词：Calcium-activated potassium channel ; Apamin ; Homeostasis ; Reaction time ; Parkinson's disease
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：519-532
• 全文大小：2556 K
• 卷排序：113

文摘

In a rat model of Parkinsonism: Upregulation of SK2 channel expression in the subthalamic nucleus. Decrease of SK3 channel expression level in the substantia nigra pars compacta. Behavioral performance in a reaction time task of 6-OHDA-lesioned rat. Impairment by SK channel blockade with apamin in the subthalamic nucleus. Improvement by SK channel blockade with apamin in the substantia nigra pars compacta.