Co-milling of telmisartan with poly(vinyl alcohol) - An alkalinizer free green approach to ensure its bioavailability
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- 作者：Jinu Isaac ; Swastika Ganguly ; Animesh Ghosh ; aghosh@bitmesra.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Telmisartan ; Poly(vinyl alcohol) ; Co-milling ; Disordered crystals ; Green pharmaceutical formulation
- 刊名：European Journal of Pharmaceutics and Biopharmaceutics
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：43-52
- 全文大小：1747 K
文摘
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Telmisartan and poly(vinyl alcohol) were co-milled in a planetary micro mill.
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The size and physical state of the telmisartan particles were depended on process parameters used.
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Dissolution of telmisartan from CG1 tablet was 96.57 ± 2.02% at 30 min.
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Bioavailability of CG 1 tablet (93.92 ± 12.84%) was comparable to innovator’s product (Micardis®).
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Absence of use of any of the alkalinizer/s in the formula, ensured the gastro environmental friendliness of the product.