Comparative investigation of methionine and novel formulation Metovitan protective effects in Wistar rats with testicular and epididymal toxicity induced by anti-tuberculosis drugs co-administration

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• 作者：Ganna M. Shayakhmetova ; ^{anna_shayakhmetova@yahoo.com} ; Larysa B. Bondarenko ; Alla K. Voronina ; Valentina M. Kovalenko
• 关键词：Methionine ; Metovitan ; Anti-tuberculosis drugs ; CYPs ; Spermatogenesis ; Testes
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：222-230
• 全文大小：1516 K
• 卷排序：99

文摘

Anti-tuberculosis drugs (ATD) repeated co-administration in rats caused testicular and epididymal disturbances. Methionine and novel formulation «Metovitan» regulated CYP2E1 and CYP3A2 mRNA expression in testes of ATD-treated rats. Methionine unaffected testicular CYP2C23 mRNA levels, while «Metovitan» normalized this parameter. Methionine and «Metovitan» prevented imbalance in testicular CYP2E1 enzymatic activity and pro/antioxidant parameters. Methionine and «Metovitan» application resulted in improvement of spermatogenesis parameters, sperm count and fertility.