Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer
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- 作者：Xuemei Gaoa ; b ; c ; 1 ; Xinchao Wuc ; 1 ; Xiao Zhanga ; b ; Wenjuan Huaa ; b ; Yajing Zhanga ; b ; Yusufu Maimaitid ; Zairong Gaoa ; b ; gaobonn@163.com" class="auth_mail" title="E-mail the corresponding author ; Yongxue Zhanga ; b
- 关键词：BRD4 ; JQ1 ; Thyroid cancer ; NIS ; C-MYC
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：469
- 期：3
- 页码：679-685
- 全文大小：1238 K
文摘
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BRD4 is upregulated in thyroid cancer tissues and cell lines.
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Inhibition of BRD4 induced cell cycle arrest and enhanced radioiodine uptake in vitro and impaired tumor growth in vivo.
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JQ1 suppressed the expression of C-MYC and promoted the expression of NIS and P21.
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JQ1 attenuated the recruitment of BRD4 to MYC promoter in thyroid cancer.