Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation
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- 作者：Snehal N. Chaudhari1 ; 4 ; Madhumati Mukherjee2 ; 4 ; Alexandra S. Vagasi1 ; Gaofeng Bi3 ; Mohammad M. Rahman2 ; 5 ; Christine Q. Nguyen1 ; Ligi Paul3 ; Jacob Selhub3 ; Edward T. Kipreos1 ; ekipreos@uga.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：11 July 2016
- 年：2016
- 卷：38
- 期：1
- 页码：33-46
- 全文大小：2892 K
文摘
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A tissue culture system maintains primary cultures of C. elegans germ cells
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Bacteria-derived folates promote germ cell proliferation both in vitro and in vivo
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Specific folates stimulate proliferation independently of their roles as vitamins
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The folate germ cell stimulatory pathway requires the folate receptor homolog FOLR-1