Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes
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- 作者：Hsu-Kun Wang<sup>asup><sup> ; sup><sup>1sup> ; Qing Wei<sup>bsup><sup> ; sup><sup>1sup> ; Zina Moldoveanu<sup>bsup> ; Warner K. Huh<sup>csup> ; Huong Lan Vu<sup>bsup> ; Thomas R. Broker<sup>asup> ; Jiri Mestecky<sup>bsup><sup> ; sup><sup>dsup><sup> ; sup><sup>mestecky@uab.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Louise T. Chow<sup>asup><sup> ; sup><sup>LTChow@uab.edu" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：HPV vaccine ; HPV antibodies ; HPV-18 neutralization ; Primary human keratinocytes ; FcRn
- 刊名：Vaccine
- 出版年：2016
- 出版时间：8 June 2016
- 年：2016
- 卷：34
- 期：27
- 页码：3171-3177
- 全文大小：1206 K
文摘
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Gardasil-immunized sera or IgG possesses strong extracellular neutralization.
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FcRn expressed on primary human keratinocytes (PHKs) mediates the uptake of IgG.
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Bound or intracellular Gardasil-immunized IgG does not neutralize HPV virions.
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Neutralization window of the immune sera is limited to 4 h in early passage PHKs.
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Growth characteristics of PHKs affect the neutralization window from 4 h to 16 h.