Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide

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• 作者：Ying-Ju Lin^a ; ^b ; ^c ; ^{yjlin.kath@gmail.com} ; Chien-Chen Lai^d ; Chih-Ho Lai^e ; Shih-Che Sue^f ; Cheng-Wen Lin^g ; ^h ; Chien-Hui Hungⁱ ; Ting-Hsu Lin^a ; Wei-Yi Hsu^a ; Shao-Mei Huang^a ; Yi-Lin Hung^f ; Ni Tien^g ; ^h ; Xiang Liu^c ; Chao-Ling Chen^j ; Fuu-Jen Tsai^a ; ^b ; ^{d0704@mail.cmuh.org.tw}
• 关键词：Enterovirus 71 ; Geniposide ; Internal ribosome entry site ; Fructus gardeniae
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：62
• 期：Complete
• 页码：206-213
• 全文大小：917 K

文摘

Fructus gardeniae has long been used by traditional Chinese medical practitioners for its anti-inflammatory, anti-oxidant, anti-tumor and anti-hyperlipidemic characteristics. Here we describe our finding that F.?gardeniae greatly reduces anti-enterovirus 71 (EV71) activity, resulting in significant decreases in EV71 virus yields, EV71 infections, and internal ribosome entry site activity. We also found that geniposide, a primary F.?gardeniae component, inhibited both EV71 replication and viral IRES activity. Our data suggest the presence of a mechanism that blocks viral protein translation. According to our findings, F.?gardeniae and geniposide deserve a closer look as potential chemopreventive agents against EV71 infections.