Structural studies on new metal derivatives of osteoporosis therapeutic aminohydroxyalkylidenebisphosphonic acids with C4 and C6 aminoalkyl chains
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- 作者：Siud Pui Man ; Majid Motevalli ; Stuart Gardiner ; Alice Sullivan and John Wilson
- 关键词：Bisphosphonate ; Aminohydroxyakylidenebisphosphonates ; Manganese ; Nickel ; Cobalt ; Zinc ; Cadmium ; Alendronate ; X-ray structures
- 刊名：Polyhedron
- 出版年：2006
- 出版时间：6 March 2006
- 年：2006
- 卷：25
- 期：4
- 页码：1017-1032
- 全文大小：798 K
文摘
Hydrothermal reactions between the bisphosphonic acid 6-amino-1-hydroxy-1,1-hexylidenebisphosphonic acid and divalent hydrated metal nitrates of cobalt, nickel or zinc, in 1:0.75 molar ratio, afforded 1:2 mononuclear dichelate products Co 1, Ni 2 and Zn 3. Similar reactions using manganese or cadmium gave the 1:2 dinuclear products Mn 4 and Cd 5 with chelate bridging as well as chelate terminal bisphosphonate ligands. In contrast to mononuclear 1 the reaction between 4-amino-1-hydroxy-1,1-butylidenebisphosphonic acid and hydrated cobalt(II) nitrate gave a dinuclear product 6. The single-crystal X-ray structures of compounds 1–6 are discussed. The C6 alkylammonium chains in dinuclear compounds 4 and 5 display interesting supramolecular structure directing effects which are different from those in related compounds with C4 alkylammonium chains.