Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1α-mediated extracellular vesicle production by endothelial cells

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• 作者：Nicholas Burnley-Hall^a ; ¹ ; Gareth Willis^b ; ¹ ; Jessica Davis^c ; D. Aled Rees^d ; Philip E. James^e ; ^{PJames@cardiffmet.ac.uk}
• 关键词：Extracellular vesicles ; Hypoxia ; Hypoxia-inducible factor ; Nitrite ; Nitric oxide
• 刊名：Nitric Oxide
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：63
• 期：Complete
• 页码：1-12
• 全文大小：2149 K
• 卷排序：63

文摘

Hypoxia-inducible factor 1α, but not 2α, mediates extracellular vesicle release in endothelial cells. Nitrite-derived nitric oxide increases HIF-1α degradation, and subsequently reduces extracellular vesicle production. This effect is attenuated by inhibition of xanthine oxidoreductase, preventing the conversion of nitrite to nitric oxide.