Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks
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- 作者：Enrico Cannavò ; 1 ; Pierre Khoueiry1 ; David A. Garfield1 ; Paul Geeleher1 ; Thomas Zichner1 ; E. Hilary Gustafson1 ; Lucia Ciglar1 ; Jan O. Korbel1 ; Eileen E.M. Furlong1 ; furlong@embl.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：enhancer ; redundancy ; shadow enhancer ; robustness ; transcriptional networks ; development
- 刊名：Current Biology
- 出版年：2016
- 出版时间：11 January 2016
- 年：2016
- 卷：26
- 期：1
- 页码：38-51
- 全文大小：3434 K
文摘
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Regulation by shadow enhancers is pervasive and complex during embryonic development
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The vast majority of genes have more than two enhancers with similar activity
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Shadow enhancers buffer genetic variation within a population, but yet appear conserved
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Evolutionary analyses suggest that they play complex and fundamental roles in development