N-Acyl-4,5-dihydro-4,4-dimethyl-N-methyl-2-thiazolamine as a chemoselective acylating agent

详细信息    查看全文

• 作者：Kim ; Taek Hyeon ; Yang ; Garp-Yeol
• 刊名：Tetrahedron Letters
• 出版年：2002
• 出版时间：December 23, 2002
• 年：2002
• 卷：43
• 期：52
• 页码：9553-9557
• 全文大小：354 K

文摘

2-Methylamino-2-thiazoline reacted with alkyl acyl halides to produce N-acyl-2-methylamino-2-thiazolines, exo-acylated product regioselectively, which were found to be highly chemoselective acylating agents for primary amine in the presence of secondary amine and for the less sterically hindered of two different primary amines.