文摘
Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH2O(CH2)2OCH2 and CH2O(CH2)4OCH2 were tested for their potency to reactivate VX-inhibited AChE. Their reactivation potency was compared with currently available oximes such as pralidoxime, obidoxime and HI-6. Appropriate constants (affinity towards the intact and inhibited enzyme, reactivation rate) characterizing the reactivation process were determined. According to the data obtained, a new oxime with CH2O(CH2)2OCH2 linker reached as high reactivation potency as HI-6. The percentage of reactivation of the oxime with CH2O(CH2)2OCH2 linker was comparable to that of obidoxime at a concentration 10−3 M. Hence, these oximes may be worthy of future development for the treatment of nerve agent intoxications, especially, with lipophilic agents such as soman and cyclosarin.