Role of synaptic feedback and intrinsic voltage-gated currents in shaping cone light responses

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• 作者：Kenyon ; Garrett T. ; Travis ; Bryan J. ; Marshak ; David W.
• 关键词：Retina ; Computer simulation ; Outer plexiform layer ; Horizontal cell
• 刊名：Neurocomputing
• 出版年：2003
• 出版时间：June, 2003
• 年：2003
• 卷：52-54
• 期：Complete
• 页码：125-133
• 全文大小：256 K

文摘

A model of the outer primate retina was used to investigate how cone light responses could be shaped by both synaptic feedback from horizontal cells and intrinsic voltage-gated conductances. Published data was used to estimate the photoconductance, convergence/divergence ratios, synaptic transfer functions, passive membrane properties and voltage-gated conductances, the latter using a Levenberg–Marquardt search algorithm. When the cone resting potential was sufficiently depolarized, synaptic feedback from horizontal cells could account for the flash response measured experimentally. Voltage-gated conductances were not significantly activated during the flash response but rather maintained the cone membrane potential inside a narrow physiological range.