Immunoglobulin G4 (IgG4)-associated pouchitis - Part of IgG4 related disease? A case series and review of the literature

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• 作者：Mohammad Bilal¹ ; ^{mbilal@wpahs.org" class="auth_mail" title="E-mail the corresponding author} ; Abhishek Gulati¹ ; ^{agulati@wpahs.org" class="auth_mail" title="E-mail the corresponding author} ; Kofi Clarke¹ ; ^{kclarke@wpahs.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Autoimmune ; IgG4 ; Pouchitis
• 刊名：Digestive and Liver Disease
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：48
• 期：7
• 页码：817-819
• 全文大小：1447 K

文摘

IgG4-mediated pouchitis was first described in 2011. The aetiology and pathogenesis of IgG4-associated pouchitis is unknown. Over the last four years, less than seventy cases of IgG-associated pouchitis have been reported from a pouchitis clinic in Cleveland.

Methods

We report the first two cases of IgG4-associated pouchitis from our inflammatory bowel disease clinic and outside of Cleveland.

Conclusion

This highlights the fact that this entity could be more common than we think. It is important for general gastroenterologists to think about IgG4-mediated disease if the patient has refractory pouchitis, so early diagnosis and referral can be made. This would avoid the cost of expensive therapy and minimize antibiotic use which is what happened in our cases prior to this diagnosis being made.