Pofut2 and Adamts9 knockouts block gastrulation in mice.
POFUT2 function in extraembryonic tissues is essential for gastrulation.
Impaired secretion of ADAMTS9 likely blocks gastrulation in Pofut2 mutants.
Loss of Pofut2 or Adamts9 in the epiblast impairs axis elongation.
Defects in amnion and/or mesendoderm likely contribute to axis defects.