Antitumor activity of endoperoxide-iron chelator conjugates鈥昫esign, synthesis and biological evaluation
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- 作者：Xing Yan1 ; Yang Yu1 ; Peng Ji ; Hui He ; Chunhua Qiao ; qiaochunhua@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anti-cancer ; Endoperoxide ; Iron chelator ; Conjugates
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：18 September 2015
- 年：2015
- 卷：102
- 期：Complete
- 页码：180-187
- 全文大小：801 K
文摘
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These endoperoxide and iron chelator conjugates inhibited cancer cell proliferation.
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These compounds displayed 2–4 fold selectivity against cancer cell vs normal cell.
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Both endoperoxide and iron-chelating moiety contributed to the biological ability.