Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia
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- 作者：Ann Van der Jeugda ; b ; Ben Vermaerckeb ; Glenda M. Hallidayc ; Matthias Staufenbield ; Jü ; rgen Gö ; tza ; j.goetz@uq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Behavior ; Executive function ; Frontotemporal dementia ; Frontotemporal lobar degeneration ; Social exploration ; Tau
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：34-43
- 全文大小：3911 K
文摘
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Tau58-2/B mice present with a tau pathology in cortical areas implicated in bvFTD.
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Tau58-2/B mice exhibit motor and sensory gating anomalies at an early age.
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With aging the mice show decreased sociability but no altered exploration.
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The mice further display increased risk-taking behaviors and executive deficits.
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First limited to spatial working memory, it later extends to instrumental memory.