Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release
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- 作者：Daniel J. Foster1 ; 8 ; Jermaine M. Wilson1 ; 8 ; Daniel H. Remke1 ; 8 ; M. Suhaib Mahmood1 ; 8 ; M. Jashim Uddin1 ; 4 ; 5 ; Jü ; rgen Wess9 ; Sachin Patel2 ; 3 ; 6 ; Lawrence J. Marnett1 ; 4 ; 5 ; Colleen M. Niswender1 ; 7 ; 8 ; Carrie K. Jones1 ; 7 ; 8 ; Zixiu Xiang1 ; 8 ; Craig W. Lindsley1 ; 4 ; 8 ; Jerri M. Rook1 ; 8 ; P. Jeffrey Conn1 ; 6 ; 7 ; 8 ; 10 ; jeff.conn@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：21 September 2016
- 年：2016
- 卷：91
- 期：6
- 页码：1244-1252
- 全文大小：2480 K
文摘
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Activation of M4 on SPNs causes a sustained inhibition of DA release
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M4-mediated reductions in DA release are dependent upon CB2 receptor activation
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M4 reversal of sensory motor gating deficits requires M4 on SPNs and CB2 receptors