Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity
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- 作者：John M. Nicoludis1 ; Sze-Yi Lau2 ; 5 ; Charlotta P.I. Schä ; rfe3 ; 4 ; Debora S. Marks3 ; Wilhelm A. Weihofen2 ; 6 ; wilhelm.weihofen@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Rachelle Gaudet2 ; gaudet@mcb.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2015
- 出版时间：3 November 2015
- 年：2015
- 卷：23
- 期：11
- 页码：2087-2098
- 全文大小：3904 K
文摘
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Clustered protocadherin EC1–3 fragments form antiparallel complexes in crystals
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A full extracellular cadherin repeat region model yields an extended molecule
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Isoform-specific conservation of interfaces explains strict homophilic specificity
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Evolutionary correlations provide support for antiparallel arrangement