Styrene-acrylonitrile trimer (SAN Trimer), a mixture o
f six isomers (
four isomers o
f 4-cyano-1,2,3,4-tetrahydro-alpha-methyl-1-naphthaleneacetonitrile [THAN] and two isomers o
f 4-cyano-1,2,3,4-tetrahydro-1-naphthaleneproprionitrile [THNP]), is a by-product o
f a speci
fic production process o
f styrene-acrylonitrile polymer. Disposition studies in
female rats were conducted to evaluate the pharmacokinetic behavior o
f [
3H]SAN Trimer
following a single intravenous administration (26 mg/kg) to nonpregnant rats; a single gavage administration (nominal doses o
f 25 mg/kg, 75 mg/kg, or 200 mg/kg in corn oil) to nonpregnant rats; and a single gavage administration (nominal dose o
f 200 mg/kg in corn oil) to pregnant and lactating rats. SAN Trimer was rapidly eliminated
from blood (
T1/2 f"" alt=""not, vert, similar"" title=""not, vert, similar"" border=""0""> 1 h)
following a single intravenous dose and
following single oral doses (
T1/2 f"" alt=""not, vert, similar"" title=""not, vert, similar"" border=""0""> 3–4 h). SAN Trimer was also rapidly excreted in the urine and
feces
following single oral doses, while total radioactivity was cleared more slowly. In pregnant rats, the concentrations o
f both radioactivity and SAN Trimer 2 h a
fter dosing were highest in the blood,
followed by the placenta, with the lowest levels in the
fetus. In lactating rats, the concentrations o
f both radioactivity and SAN Trimer were higher in milk than in maternal blood. Total radioactivity and SAN Trimer blood concentrations in nonpregnant, pregnant, and lactating rats were both higher in lactating rats compared to nonpregnant and pregnant rats.