Human Pegivirus (HPgV) was formerly called GB virus C interacts with NK cells.
HPgV particles inhibited NK cell release of IFN-纬 following IL-12 stimulation.
A peptide within the HPgV E2 protein was sufficient to inhibit NK cell function.
This peptide inhibited Tyk2 and STAT 4 activation and tyrosine was required.
HPgV did not inhibit the cytolytic functions of NK cells.