Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor
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- 作者：M.J. Gó ; maraa ; mariajose.gomara@iqac.csic.es" class="auth_mail" title="E-mail the corresponding author ; V. Sá ; nchez-Merinob ; A. Paú ; sa ; A. Merino-Mansillab ; J.M. Gatellb ; c ; E. Yusteb ; I. Haroa ; isabel.haro@iqac.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acm ; acetamidomethyl ; ACN ; acetonitrile ; Dbz ; diaminobenzoyl ; DHB ; 2 ; 5-dihydroxybenzoic acid ; DIPEA ; diisopropylethylamine ; FP ; fusion peptide ; GBV-C ; GB virus C ; HAART ; highly active antiretroviral therapy ; HATU ; 2-(1H-7-azabenzotriazole-1-yl)-1 ; 1 ; 3 ; 3-tetramethyluronium hexafluorophosphate methanaminium ; HB ; helix bundle ; HT ; head-to-tail ; LUV ; large unilamelar vesicles ; mAb ; monoclonal antibody ; MPAA ; 4-mercaptophenylacetic acid ; MPER ; membrane proximal external region ; NBD ; 6-(7-nitrobenzofur
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1139-1148
- 全文大小：1056 K
文摘
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E1 GBV-C protein is a source of peptides for the development of anti-HIV therapies
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E1P47 shows antiviral activity against HIV-1 viruses from clades A, B, C, D and AE
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The E1P47 peptide interacts with the HIV-1 Fusion Peptide