Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway
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- 作者：Hee-Ju Kima ; Chang-Hee Kanga ; b ; Rajapaksha Gedara Prasad Tharanga Jayasooriyaa ; Matharage Gayani Dilsharaa ; Seungheon Leea ; Yung Hyun Choic ; Yong Taek Seod ; Gi-Young Kima ; immunkim@jejunu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrangenol ; Nitric oxide ; Nuclear factor-κB ; Heme oxygenase-1 ; Nuclear factor erythroid 2-related factor 2
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：61-69
- 全文大小：1117 K
文摘
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Hydrangenol was isolated from Hydrangea macrophylla.
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Hydrangenol inhibits LPS-induced nitric oxide production possibly by regulating iNOS expression in BV2 microglial cells.
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Hydrangenol downregulates iNOS expression by suppressing NF-κB activity.
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Nrf2-meidated HO-1 expression plays an important role in hydrangenol-mediated NO production.