Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma
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- 作者：Valery Vilchez ; M.D.a ; b ; Lilia Turcios ; Ph.D.a ; Yekaterina Zaytseva ; Ph.D.c ; Rachel Stewart ; D.O.c ; Eun Y. Lee ; M.D.d ; Erin Maynard ; M.D.a ; Malay B. Shah ; M.D.a ; Michael F. Daily ; M.D.a ; Ching-Wei D. Tzeng ; M.D.a ; Daniel Davenport ; Ph.D.a ; Ana Lia Castellanos ; M.D.a ; Steven Krohmer ; M.D.e ; Peter J. Hosein ; M.D.f ; Bernard Mark Evers ; M.D.a ; c ; Roberto Gedaly ; M.D.a ; rgeda2@uky.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Liver cancer stem cells ; Hepatocellular carcinoma ; Liver transplantation ; Outcomes ; Prognostic factors
- 刊名：The American Journal of Surgery
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：212
- 期：2
- 页码：238-245
- 全文大小：957 K
文摘
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CD44 and CD133, correlated with tumor differentiation and elevated AFP levels.
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In combination with MVI, CD44 and CD133 predict tumor recurrence and patient survival.
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This is the first report correlating LCSC markers and poor prognosis in HCC after OLT.