New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse
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- 作者：Shimi Bardaa ; b ; shimib@tlvmc.gov.il" class="auth_mail" title="E-mail the corresponding author ; Leah Yogeva ; Gedalia Paza ; Haim Yavetza ; Ron Hausera ; Haim Breitbartb ; Sandra E. Kleimana
- 关键词：Brdt ; Spermatogenesis ; Infertility ; Bromodomain
- 刊名：Gene Expression Patterns
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：20
- 期：2
- 页码：130-137
- 全文大小：1991 K
文摘
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The testes of Brdt mutant mice aged 8 weeks exhibited complete spermatocyte maturation arrest.
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Weights of testes and accessory glands and testosterone levels of the mutant mice aged 8 weeks were significantly reduced.
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The mutant mice had delayed puberty, with normal levels of testosterone and accessory gland weights at older ages.
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The presence of the BRDT protein was identified in the mice pituitary gland.