Aging-dependent decline of IL-10 producing B cells coincides with production of antinuclear antibodies but not rheumatoid factors
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- 作者：Kornelis S.M. van der Geesta ; 1 ; k.s.m.van.der.geest@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Pedro G. Lorencettia ; 1 ; Wayel H. Abdulahada ; Gerda Horsta ; Minke Huitemaa ; Caroline Roozendaalb ; Bart-Jan Kroesenb ; Elisabeth Brouwera ; Annemieke M.H. Bootsa
- 关键词：ANA ; anti-nuclear antibody ; RF ; rheumatoid factor ; IL-10 ; interleukin-10 ; TNF-α ; tumor necrosis factor α
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：24-29
- 全文大小：943 K
文摘
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Pro-inflammatory TNF-α + B cells are maintained in the circulation of aged humans.
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In essence, IL-10 + B cells are decreased in the circulation of aged humans.
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ANAs and RFs are associated with distinct IL-10 + B cell maintenance in the elderly.