Analysis of mitochondrial structure and function in the Drosophila larval musculature
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- 作者：Zong-Heng Wanga ; Cheryl Clarkb ; Erika R. Geisbrechta ; b ; geisbrechte@ksu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATP ; adenosine triphosphate ; AEL ; after egg laying ; CMT2A ; Charcot&ndash ; Marie&ndash ; Tooth Type 2A ; ConA ; concanavalin A ; Drp1 ; dynamin-related protein ; DOA ; dominant optic atrophy ; GFP ; green fluorescent protein ; IFM ; indirect flight muscle ; IMF ; intermyofibrillar ; IMM ; inner mitochondrial membrane ; LRRK2 ; leucine-rich repeat kinase 2 ; L3 ; third instar larvae ; ΔΨm ; mitochondrial membrane potential ; mtDNA ; mitochondrial DNA ; Mfn1 ; mitofusin 1 ; Mfn2 ; mitofusin 2 ; Opa1 ; optic atrophy 1 ; OMM ; outer
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：26
- 期：Complete
- 页码：33-42
- 全文大小：2402 K
文摘
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Altered mitochondrial dynamics underlie the pathology of degenerative disease.
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The Drosophila larval musculature is a good model to study mitochondrial behavior.
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Mitochondrial muscle organization is conserved between fly and mammalian muscles.
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Mitochondrial dynamics can be imaged and quantified in larval muscle tissue.