Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms

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• 作者：Rawan Eid ; Nagla T.T. Arab ; Michael T. Greenwood ; ^{michael.greenwood@rmc.ca}
• 关键词：Fe3  ; + ;   ; Ferric ion ; Fe+  ; 2 ; ferrous ion ; GI ; gastrointestinal tract ; LIP ; Labile Iron Pool (LIP) ; NBIA ; neurodegeneration with brain iron accumulation ; NTBI ; Non-Transferrin Bound Iron ; PCD ; programmed cell death ; RBC ; red blood cell ; RCD ; Regulated cell death ; ROS ; reactive oxygen species ; Tf ; transferrin (Tf)
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：399-430
• 全文大小：2567 K
• 卷排序：1864

文摘

Iron is both essential and toxic for biological systems Iron can induce cell death by generating free radicals as it interconverts between ferrous (Fe2 +) and ferric (Fe3 +) forms Elaborate mechanisms have evolved to absorb, re-cycle and store iron while minimizing toxicity The existing literature suggests that iron toxicity is common Our analysis suggests that existing regulatory processes are more than adequate to limit toxicity even in iron overload