HOX genes: Major actors in resistance to selective endocrine response modifiers
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- 作者：Kideok Jina ; b ; kjin2@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Saraswati Sukumara ; saras@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HOX gene ; Endocrine resistance ; Non-coding RNA ; Breast cancer
- 刊名：Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1865
- 期：2
- 页码：105-110
- 全文大小：495 K
文摘
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HOX genes are often overexpressed in breast cancer.
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Hormones regulate expression of many HOX genes.
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HOX genes and miRNAs/ncRNA in the HOX cluster can contribute to endocrine resistance.
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Targeting specific HOX gene can overcome endocrine-resistance in breast cancer.